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TitleTripping over the Truth The Metabolic Theory of Cancer
Author
LanguageEnglish
File Size1.1 MB
Total Pages223
Table of Contents
                            Title Page
Copyright Page
Contents
In the Beginning
Part 1: How Cancer Became Known as a Genetic Disease
	Chimney Boys
	Chaotic Chromosomes
	Is Cancer Infectious?
	Warburg’s War
	The Secret of Life
	A Question That Had Passed Him By
	Everything Was in a Fog
Part 2: Chemotherapy and the Gates of Hell
	Ying and Yang
	MOPP
	Total Therapy
	“That Son of a Bitch”
Part 3: Breakthroughs and Disappointments
	Into the Dustbin of History
	A Flickering Ember
	PET Scan
	A New Era
	An Old Target Is New Again
	The Good, the Bad, and the Ugly
	“If I Hadn’t Seen It with My Own Eyes, I Wouldn’t Have Believed It”
Part 4: Dark Matter
	“Is It Possible to Make Sense Out of This Complexity?”
	A Paradigm Shift
	The Tortoise and the Hare
Part 5: Watson Reconsiders
Part 6: Mitochondria: An Old Theory Is New Again
	Things May Not Be as They Seem
	Superfuel
	Nemesis
	The Most Important Game in Town
	Gorgeous in Concept (More of the Same)
	Press-Pulse
Part 7: Where Do We Go from Here?
Appendix A
	Putting Metabolic Therapies to Work
	Implementing the Restricted Ketogenic Diet
	Ketogenic D Diet Therapy
	Miriam Kalamian’s Story
	The “Pulse”, the power of synergy
Appendix B
Notes
                        
Document Text Contents
Page 2

TrippingOver theTruth

The Return of the MetabolicTheory of Cancer Illuminates a
New and Hopeful Path to a Cure

Travis Christofferson

Page 222

Nemesis
T Seyfried, Zuccoli, Metabolic management of glioblastoma multiforme using
standard therapy together with a restricted ketogenic diet: Case Report. Nutr
Metab (Lond). 2010; 7: 33

Zuccoli, email exchange with the author
Veech R, Ketoacids? Good medicine? Trans Am Clin Climatol Assoc.

2003, 114: 149–163.
Veech RL, Chance B, Kashiwaya Y, Lardy HA, Cahill GF, Jr.: Ketone

bodies, potential therapeutic uses. IUBMB Life 2001, 51:241-247.
Stafford, P., et al., The ketogenic diet reverses gene expression patterns

and reduces reactive oxygen species levels when used as an adjuvant therapy for
glioma. Nutr Metab (Lond), 2010. 7: p. 74.

The Most Important Game in Town
Watson J: Oxidants, antioxidants and the current incurability of metastatic
cancers. Open Biol 2013, 3:120144.

Abdelwahab MG, Fenton KE, Preul MC, Rho JM, Lynch A, Stafford P,
Scheck AC: The ketogenic diet is an effective adjuvant to radiation therapy for
the treatment of malignant glioma. PLoS One 2012, 7:e36197.

Aykin-Burns N, Ahmad IM, Zhu Y, Oberley LW, Spitz DR: Increased
levels of superoxide and H2O2 mediate the differential susceptibility of cancer
cells versus normal cells to glucose deprivation. Biochem J 2009, 418:29-37.

Trachootham D, Alexandre J, Huang P. Targeting cancer cells by ROS-
mediated mechanisms: a radical therapeutic approach? Nat Rev Drug Discov.
2009;8: 579– 91.

Lizzia Raffaghello, Fernando Safdie, Giovanna Bianchi, Tanya Dorff,
Luigi Fontana, Valter D Longo Fasting and differential chemotherapy protection
in patients. Cell Cycle. 2010 November 15; 9(22): 4474–4476

Marsh J, Mukherjee P, Seyfried TN: Drug/diet synergy for managing
malignant astrocytoma in mice: 2-deoxy-D-glucose and the restricted ketogenic
diet. Nutr Metab (Lond) 2008, 5:33.

Stafford, P., et al., The ketogenic diet reverses gene expression patterns
and reduces reactive oxygen species levels when used as an adjuvant therapy for
glioma. Nutr Metab (Lond), 2010. 7: p. 74.

Raffaghello, L., et al., Fasting and differential chemotherapy protection in
patients. Cell Cycle, 2010. 9(22): p. 4474-6.

Page 223

Zuccoli, G., et al., Metabolic management of glioblastoma multiforme
using standard therapy together with a restricted ketogenic diet: Case Report.
Nutr Metab (Lond), 2010. 7: p. 33.

Gorgeous in Concept (More of the Same)
Seyfried, Cancer as a Metabolic Disease

Couzin-Frankel J. Immune therapy steps up the attack. Science. 2010. 330:
440-3.

Press Pulse
D’Agnostino, interview with the author

Poff AM, Ari C, Seyfried TN, D’Agostino DP: The ketogenic diet and
hyperbaric oxygen therapy prolong survival in mice with systemic metastatic
cancer. PLoS One 2013, 8:e65522.

Seyfried TN, Flores RE, Poff AM, D’Agostino DP: Cancer as a metabolic
disease: implications for novel therapeutics. Carcinogenesis 2014, 35:515-527.

“You should come out healthier” Seyfreid, interview with the author.

Part 7: Where Do We Go From
Here?

The Emperor of All Maladies, Siddhartha Mukherjee

WHO Cancer Statistics: http://live.wsj.com/video/who-warns-of-tidal-
wave-of-cancer/00B6831E-8D99-4CD0-9166-7FF8DDB7A09B.html?
mod=WSJ_article_outbrain&obref=obnetwork#!00B6831E-8D99-4CD0-9166-
7FF8DDB7A09B

“sardonic sense of humor”: Rous P. The challenge to man of the neoplastic
cell. Cancer Res. 1967, (11):1919-24

“vehemently argued”: Rous P. Surmise and fact on the nature of cancer.
Nature. 1959, 183(4672):1357-61

http://live.wsj.com/video/who-warns-of-tidal-wave-of-cancer/00B6831E-8D99-4CD0-9166-7FF8DD-B7A09B.html?mod=WSJ_article_outbrain&obref=obnetwork#!00B6831E-8D99-4CD0-9166-7FF8DDB7A09B

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