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TitleTRI-CARBONYL BASED RADIOPHARMACEUTICALS
LanguageEnglish
File Size4.1 MB
Total Pages194
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RE(I) TRI-CARBONYL BASED RADIOPHARMACEUTICALS; SYNTHESIS, IN

VITRO STUDIES, AND PROTEIN COMPLEXATION

A Dissertation

Presented to

The Graduate Faculty of The University of Akron

In Partial Fulfillment

Of the Requirements for the Degree

Doctor of Philosophy

Sarah L. Binkley

August 2016

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Table 2.1: Crystal data and structure refinement for 2.

Identification code 2

Empirical formula ReC8H19N3O5Cl

Formula weight 458.91

Temperature 100(2) K

Wavelength 0.71073 Å

Crystal system Monoclinic

Space group P2(1)/n

Unit cell dimensions, Å a = 6.8635 (18)

b = 12.951 (3)

c = 15.970 (4)

, deg 93.803 (4)

Volume, Å3 1416.5 (6)

Z 4

Density (calculated) 2.152 Mg/m3

Absorption coefficient 8.783 mm-1

F(000) 880

Reflections collected 11,742

Independent reflections 3210

Goodness-of-fit on F2 1.074

Final R indices [I>2sigma(I)] R1 = 0.0300, wR2 = 0.0658

R indices (all data) R1 =0.0366, wR2 = 0.0677

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Table 2.2: Crystal data and structure refinement for 3.

Identification code 3

Empirical formula ReC8H15N3O7Cl

Formula weight 486.83

Temperature 100(2) K

Wavelength 0.71073 Å

Crystal system Monoclinic

Space group Cc

Unit cell dimensions, Å a = 13.579 (4)

b = 8.441 (3)

c = 11.878 (4)

, deg 98.193 (4)

Volume, Å3 1347.5 (6)

Z 4

Density (calculated) 2.370 Mg/m3

Absorption coefficient 9.250 mm-1

F(000) 904

Reflections collected 5493

Independent reflections 2819

Goodness-of-fit on F2 0.869

Final R indices [I>2sigma(I)] R1 = 0.0245, wR2 = 0.0490

R indices (all data) R1 =0.0271, wR2 = 0.0571

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216. Lecina, J.; Palacios, Ã.; Atrian, S.; Capdevila, M.; Suades, J.; Journal of Biological

Inorganic Chemistry 2015, 20(3), 465-474.

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