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TitleProgress in Immunology: Vol. VII: Proceedings of the 7th International Congress Immunology Berlin 1989
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Progress in Immunology
Vol. VII
Proceedings of the 7th International Congress of Immunology
Berlin 1989

Editors: F. Melchers
E.D. Albert, H. von Boehmer, M.P. Dierich, L. Du Pasquier,
K. Eichmann, D. Gemsa, O. Gotze, J.R. Kalden, S.H.E. Kaufmann,
H. Kirchner, K. Resch, G. Riethmiiller, A. Schimpl, C. Sorg,
M. Steinmetz, H. Wagner, H. G. Zachau

Editorial Assistance: L. Nicklin

With 255 Figures and 184 Tables

Springer-Verlag Berlin Heidelberg New York
London Paris Tokyo Hong Kong

Page 687

informations about lymphokine functions in a whole body. Approaches to
investigate such functions may not be easy but deeply demanded.
Depletion of lymphokine-producing cells by introducing toxinic genes
driven by lymphokine gene promoters as a transgene or destroying the
lymphokine gene by homologous recombination using embryonic stem cells
might be very useful for such analyses.

Clinical application Should Be pone with an Extreme Care and a Good
Knowledge of in Vivo Effects.

As in vivo functions of lymphokines are often unexpected and
unpredictable from in vi tro studies, clinical applications of them
should be done with an extreme care of possible side effects. If we
are able to avoid unpleasant side effects by precise targeting ,
lymphokines could be most powerful and promising drugs because of
their strong and diverse activities. A drug delivery system that
allows focused administration to target site (s) such as malignant
!-umo"rs should be developed to fully utilize the effect of lymphokines.

Rapid progress of Studies on Regulation of Lymphokine Expression Is

Regulation of lymphokine gene expression is essential for
understanding of the immune response. Though we did not describe about
such studies in this review, both cis-acting control element like NFkB
binding site (Lowenthal et al., in press) and trans-acting factors
like interferon regulating factors (Miyamoto et al., 1988) have been
already identified. Rapid progress in this field will provide us with
valuable and important informations about ordinate or competitive
regulation of many lymphokine genes.

Structural Studies on Lymphokines and Their Receptors Will Facilitate
piscovery of antagonists and agonists of Lymphokines

A large scale production of pure lymphokines using recombinant DNA
technology made it possible to analyze the three dimensional structure
of lymphokines by X-ray crystalography. Such approach to elucidation
of the IL-2 structure was initiated (Brandhuber et al., 1987).
Elucidation of the three dimensional structure of the lymphokine and
its receptor will help us to design antagonists or agonists. A
primitiv~ trial using soluble form of the IL-2 receptor L chain showed
immune suppressive activities in vitro (Kondo et al.,1988).

More Informations on Molecular Mechanisms of Signal Transduction are

Although we now know the structure of several lymphokine receptors,
little is known about their signal transduction mechanism. Most
lymphokine receptors (ligand binding molecules) do not seem to have
obvious catalytic domains. We might be able to identify another yet
unknown type of mechanism for lymphokine signal transduction.


Page 688


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Enokihara H, Furusawa S, Nakakubo H, Kajitani H, Nagashima S, Saito K,

Shishido H, Hitoshi Y, Takatsu K, Noma T, Shimizu A, Honjo T (1989)
Blood 73:1809-1813

Hatakeyama H, Tsudo H, Hinamoto S, Kono T, Doi T, Hiyata T, Hiyasaka
H, Taniguchi T (1989) Science 244:551-556

Ishida Y, Nishi H, Taguchi 0, Inaba K, Hattori H, Hinato N, Kawaichi
M, Honjo T (in press) J Exp Med

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Kondo S, Shimizu A, Saito Y, Kinoshita M, Honjo T (1986b) Proc Natl
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Lowenthal JW, Ballard OW, Bohnlein E, Greene WC (in press) Immunol.

Hiyamoto H, Fujita T, Kimura Y, Haruyama H, Harada H, Sudo Y, Hiyata
T, Taniguchi T (1988) Cell 54:903-913

Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL (1986) J
Immunol 136:2348-2357

Nikaido T, Shimizu A, Ishida N, Sabe H, Teshigawara K, Haeda M,
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Noma T, Nakakubo H, Sugita H, Kumagai S, Haeda H, Shimizu A, Honjo T
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Paul WE (1989) Cell 57:521-524
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Page 1373

B. Dupont, Cornell
University (Ed.)

Springer-Verlag Berlin
Heidelberg New York
London Paris Tokyo
Hong Kong

Vol. 1: Histocompatibility Testing 1987
Vol. 2: Immunogenetics and Histocompatibility

1989. LIV, 1701 pp. 550 figs. (in 2 vols., not available
separately). Hardcover DM 690,-
ISBN 3-540-96826-1
Vol. 1: LIV, 1084 pp. 362 figs.
Vol. 2: XLVIII, 617 pp. 188 figs. 8 color plates.

Volume 1, Histocompatibility Testing 1987, is the
result of the Tenth International Histocompatibility
Workshop. Over 360 laboratories worldwide partici-
pated in collaborative projects, including the
biochemical analysis ofHLA antigens, identification
of polymorphic HLA determinants detected by
T-Iymphocyte clones and a comprehensive analysis
of Southern Blot with HLA-DNA probes. The detail
of the Joint Reports from the individual workshop
components, with the accompanying figures, tables
and pictures of gels from the biochemical studies, as
well as Southern Blots, constitute an "Atlas for
Factors of the HLA System."
Volume 2, Immunogenetics and Histocompatibility,
contains 251 invited papers presented at the Interna-
tional Conference in New York City, supplemented
by a series of review papers covering selected topics
on the molecular biology of the major histocompati-
bility complex.
Together, the two volumes provide up-to-date
authoritative information on the molecular biology
of the HLA system and serve as a useful handbook
on the state ofthe art of basic research on HLA and
the application of clinical histocompatibility testing.

Page 1374

P.Ivanyi, Amsterdam

Springer-Verlag Berlin
Heidelberg New York
London Paris Tokyo
Hong Kong

Realm of

Proceedings of a meeting in memory of
Professor Milan HaSek, October 5-8, 1988
in Ommen/Amsterdam

Foreword by M. Boiron

1989. XIX, 314 pp. 72 figs., 60 tabs. Hardcover
DM 64,- ISBN 3-540-51056-7

Any professional concerned with immunology
will be interested in this book dedicated to the
memory of Milan HaSek, former director of the
Prague Institute of Experimental Biology and
Genetics. Prof. HaSek was a congenial scientist
and most amiable person - a personal friend of
almost all leading immunologists around the
world. He was displaced from his post of director
in 1970, yet had a lasting impact upon his
students and the group known as the Prague
School of Immunogenetics.
The topics covered in the contributions range
from tolerance, immune network, and immuno-
genetics to the immunology of bacterial and viral
infections. The are written by 27 of Prof Hasek's
former coworkers who emigrated to western
contries around or after 1968 and became well-
known and distinguished scientists in the field.
The papers include their personal reflections of
the Prague Institute, their impressions upon
arriving abroad and their interesting experimental
work since then. The book also provides a
complete bibliography of their publications after
leaving Czechoslovakia.

Prices are subject to change without notice.

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