Download GENERAL PHARMACOLOGY -Part 1.pdf PDF

TitleGENERAL PHARMACOLOGY -Part 1.pdf
Tags Injection (Medicine) Pharmacy Clinical Medicine
File Size1.4 MB
Total Pages49
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Page 1

GENERAL PHARMACOLOGYGENERAL PHARMACOLOGY

Dr. Hanan HagarDr. Hanan Hagar
MPHL MPHL -- 231231

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Recommended booksRecommended books

Basic and Clinical Pharmacology Basic and Clinical Pharmacology
byby KatzungKatzung

Pharmacology Pharmacology
byby RangRang

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Gastrointestinal tract (GIT).Gastrointestinal tract (GIT).
–– Oral Oral
–– SublingualSublingual
–– Rectal Rectal
Parenteral administration = injections.Parenteral administration = injections.
Topical applicationTopical application

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Factors Affecting BioavailabilityFactors Affecting Bioavailability
Molecular Weight.Molecular Weight.
Lipid/Water Partition Coefficient.Lipid/Water Partition Coefficient.
Pka.Pka.
Drug Formulation.Drug Formulation.
First pass metabolismFirst pass metabolism
pH of gut.pH of gut.
Rate of gastric emptying.Rate of gastric emptying.
Intestinal motility (Transit Time).Intestinal motility (Transit Time).
Surface area available for absorption.Surface area available for absorption.
Drug interactions Drug interactions
Food Food

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FoodFood
Reduces absorptionReduces absorption
aspirin, penicillin V,aspirin, penicillin V,
tetracycline, erythromycin.tetracycline, erythromycin.

Increases absorptionIncreases absorption
PropranololPropranolol, diazepam, , diazepam, dicoumaroldicoumarol..

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