Download Chirality in Pharmaceutical Synthesis PDF

TitleChirality in Pharmaceutical Synthesis
File Size509.9 KB
Total Pages12
Document Text Contents
Page 1

Chirality inChirality in
Pharmaceutical Pharmaceutical 

synthesissynthesis

Page 11

An alternative to Synthesis of desired optical isomer is Chiral Resolution

Separation methods of racemic compounds into their 
enantiomers

Resolution by crystallisation
First achieved by Louis Pasteur (discovered the concept of optical 
activity). Here racemic mixture will crystalise as enantiopure
compounds after saturation in Sodium Ammonium T artrate

 Na+OOC-CH(OH)-CH(OH)-COO NH3+

Chiral resolving agents

T o the racemic mixture
optically pure reagents
are added.Diesteromers
are formed often as
salts, which can be
separated.
Deprotonation then

 follows. Reagents used 
include tartaric acid and 
brucine.

Similer Documents