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Titleassay_alumina and Magnesia Oral Suspension
Tags Physical Sciences Materials Chemical Substances Titration
File Size44.8 KB
Total Pages3
Document Text Contents
Page 1

Name: Mas, Mylyn L. Date Submitted: 10/28/16

Pharm Chem 1! Se"ti#n: P$6 Date Per%#rmed: 11/0!/16

&'(eriment N#. !

C#m(le'#metry

Assay o Assay of Alumf Alumina and Magina and Magnesia Onesia Oral Susperal Suspension for nsion for AluminuAluminum Content m Content

). D*+* *ND &S-L+S

*. #lume/eihin Measurements

Sam(le 1: *lumina and Manesia ral Sus(ensi#n

#lume #% Sam(le St#"3 S#luti#n4:

+rial 14 : 2!0.0 mL +rial 24 : 2!0.0 mL

*li5u#t: +rial 14 : 10.0 mL +rial 24 : 10.0 mL lan34: 10.0 mL 7ater4

. +itrati#n Data

#lume #% +itrant -sed:

VVoolluumme e RReeaaddiinngg TTrriiaal l 11 TTrriiaal l 22 BBllaannk k ((nn//a a bbaasseed d oonn

USP)USP)

Initial ReadingInitial Reading 0.00 mL 0.00 mL 2!.0! mL

Final ReadingFinal Reading 2!.0! mL 2!.0! mL !0.10 mL

Total Volume UsedTotal Volume Used 2!.0! mL 2!.0! mL 2.0! mL

#lumetri" S#luti#n -sed: Dis#dium &detate

N%9 0.61;

Pre(ared by: il#ria, L#<ely Mae .

#lume #% a"3 +itrant -sed:

VVoolluumme e RReeaaddiinngg TTrriiaal l 11 TTrriiaal l 22 BBllaannk k ((nn//a a bbaasseed d oonn

USP)USP)

Initial ReadingInitial Reading 0.00 mL 0.00 mL 1.! mL

Final ReadingFinal Reading 1.60 mL 1.! mL .;! mL

Page 2

Total Volume UsedTotal Volume Used 1.60 mL 1.! mL 0 .0 mL

#lumetri" S#luti#n -sed: 0.0! M =in" Sul%ate

N%9 0.!8

Pre(ared by: Cle# aliente

Calulated ! o" #ti$e Ingredient%Calulated ! o" #ti$e Ingredient%

&abelled Claim% 22' mg/' m&&abelled Claim% 22' mg/' m&

Trial 1Trial 1: 10. > #% *l$4 in Sam(le Trial 2Trial 2: 10!.8; > #% #% *l$4 in Sam(le

> De<iati#n et7een +rials: 0.881 >

*""e(tan"e "riteria: 0.0 >?110.0>4

Sam(le: P#SS T* +FFICI#& R,UIR-.TP#SS T* +FFICI#& R,UIR-.T

)). D)SC-SS)N

* sus(ensi#n #% *lumina and Manesia ral Sus(ensi#n Labelled Claim: 22! m/!mL4

7as assayed. Sam(le is "#m(#sed #% 7hite sus(ended (arti"les that needs t# be sha3en 7ell

be%#re use. )t 7as st#red in a 7hite (lasti" "#ntainer that 7as tihtly "l#sed. +he sam(le 7as n#t

%reshly (re(ared and 7as #(ened durin the 7ee3 #% the assay "t#ber 2?28, 20164.

+7# titrati#n trials 7ere (er%#rmed %#r the assay #% *luminum $ydr#'ide "#ntent #%

*lumina and Manesia ral Sus(ensi#n 7ith Dis#dium &detate S as the e'"ess titrant and

0.0! M =in" Sul%ate S as the ba"3 titrant. * 0.881 > de<iati#n bet7een b#th trials 7as

a"5uired. +he > de<iati#n <alue %alls 7ithin the @ > de<iati#n rane, indi"atin that the results

#btained are #% hih (re"isi#n. )n additi#n, a 10. > and 10!.8;> a"ti<e inredient %#r +rial

1 and +rial 2, res(e"ti<ely 7ere "al"ulated . +he > a"ti<e inredient #% the sam(le met the

a""e(tan"e "riteria set %#r *luminum $ydr#'ide "#ntent #% *lumina and Manesia ral

Sus(ensi#n 0.0?110.0 >4 7hi"h means that the sam(le is #% ##d 5uality.

* m#di%i"ati#n #% the #riinal (r#"edure d#ne is the am#unt #% dithiA#ne t# be added #n

the sam(le. +he (r#"edure indi"ates additi#n #% 2 mL #% dithiA#ne, h#7e<er, sin"e at this <#lume
n# "#l#r is e<ident sam(le is still "#l#rless4 a 6 mL <#lume #% dithiA#ne 7as used. *t 6 mL, the

reen?<i#let "#l#r be"ame e<ident. +his additi#n #% <#lume has n# sini%i"ant e%%e"t #n the assay

sin"e the %#rmati#n #% the Ain" dithiA#nate "#m(le' is #nly de(endent i% there are already %ree,

e'"ess Ain" #n the rea"ti#n mi'ture and n#t #n the am#unt #% dithiA#ne (resent. )n additi#n, the

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