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TitleAnalytical Profiles of Drug Substances 10
Author
LanguageEnglish
File Size21.5 MB
Total Pages727
Table of Contents
                            Cover
Editorial Board
Affiliations of Editors
Preface
Azathioprine
Aminosalicylic acid
Benzyl Benzoate
Clindamycin hydrochloride
Codeine Phosphate
Colchicine
Cyanocobalamin
Emetine hydrochloride
Glibenclamide
Heroin
Hydrochlorothiazide
Ketoprofen
Methylphenidate hydrochloride
Nabilone
Natamycin
Oxytocin
Penicillamine
Probenecid
Salbutamol
Succinylcholine choride
Trioxsalen
Errata for volume 9
Cumulative Index
                        
Document Text Contents
Page 1

Analytical Profiles
of

Drug Substances
Volume 10

Edited by

Klaus Florey
The Squibb Institute for Medical Research

New Brunswick, New Jersey

Contributing Editors
Rafik Bishara Lee T. Grady

Glenn A. Brewer, Jr.
John E. Fairbrother

Hans-Georg Leemann
Joseph A. Mollica

Bruce C. Rudy
Compiled under the auspices of the

Pharmaceutical Analysis and Control Section
Academy of Pharmaceutical Sciences

ACADEMIC PRESS 1981
A Subsidiary of Harcourt Brace Jovanovich, Publishers

New York London Sydney Toronto San Francisco

Page 2

Norman W. Atwater
Rafik Bishara
Jerome I. Bodin
Glenn A. Brewer, Jr.
Lester Chafetz
Edward M. Cohen
John E. Fairbrother
Klaus Florey

EDITORIAL BOARD

Salvatore A. Fusari
Lee T. Grady
Boen T. Kho
Hans-Georg Leeman
Joseph A. Mollica
Gerald J . Papariello
Bruce C. Rudy
Milton D. Yudis

Academic Press Rapid Manuscript Reproduction

Page 363

362 DOROTHY K. WYATT AND LEE T. GRADY

F i g . 2a . P r o t o n NMR s p e c t r u m of heroin base.

- .-_A,-

Fig. 2b.

1200

P r o t o n NMR s p e c t r u m of heroin h y d r o c h l o r i d e .

Page 364

HEROIN 363

Spectral assignments are listed in Table I

Table I

'H NMR Spectral Assignments for Heroin [48]

Chemical Shift
PPm ( 6 ) Multiplicity

2.27, 2.11
2.88
3.33
3.70
5.45
5 . 2 1
5.73
6.87
6.66

2.2.2 Carbon-13 Spectrum

The carbon-13 spectra

Characteristic of proton

acetyl
N-methyl

10
9
a

596
7
1
2

is presented in Figure 3.

Spectral assignments are listed in Table XI.

Table I1

I3C NMR Spectral Assignments for Heroin 1711

Chemical Shift Multiplicity - Carbon Number

119.1
121.6
132.0

d 1
d 2
S 3

Page 726

734 CUMULATIVE INDEX

Fluphenazineenanthate, 2,245; 4,523
Fluphenazine hydrochloride, 2, 263; 4, 518
Flurazepam hypochloride, 3, 307
Gentamicin sulfate, 9, 295; 10, 731
Glibenclamide, 10, 337
Gluthethimide, 5, 139
Gramicidin, 8, 179
Griseofulvin, 8, 219, 9, 583
Halcinonide, 8, 251
Haloperidol, 9, 341
Halothane, 1, 119; 2, 5’73
Heroin, 10, 357
Hexetidine, 7, 277
Hydralazine hydrochloride, 8, 283
Hydrochlorothiazide, 10, 405
Hydroflumethiazide, 7, 297
Hydroxyprogesterone caproate, 4, 209
Hydroxyzine dihydrochloride, 7, 319
Iodipamide, 3, 333
Isocarboxazid, 2, 295
Isoniazide, 6, 183
Isoprppamide, 2, 315
Isosorbide dinitrate, 4, 5!25; 5, 556
Kanamycin sulfate, 6, 259
Ketamine, 6, 297
Ketoprofen, 10, 443
Khellin, 9, 371
Leucovorin calcium, 8, 315
Levarterenol bitartrate, 1 , 49; 2, 573
Levallorphan tartrate, 2, 339
Levodopa, 5, 189
Levothyroxine sodium, 5, 225
Lorazepam, 9, 397
Meperidine hydrochloride, 1, 175
Meprobamate, 1, 209; 4, 519
6-Mercaptopurine, 7, 343
Methadone hydrochloride, 3, 365; 4, 519; 9

Methaqualone, 4, 245, 519
Methimazole, 8, 351
Methotrexate, 5, 283
Methoxsalen, 9, 427
Methyclothiazide, 5, 307
Methylphenidate hydrochloride, 10, 473
Methyprylon, 2, 363
Metronidazole, 5, 327
Minocycline, 6, 323
Nabilone, 10, 499
Nadolol, 9, 455; 10, 732
Nalidixic acid, 8, 371

60 1

Natamycin, 10, 513
Neomycin, 8, 399
Nitrazepam, 9, 487
Nitrofurantoin, 5, 345
Nitroglycerin, 9, 519
Norethindrone, 4, 268
Norgestrel, 4, 294
Nortriptyline hydrochloride, I , 233; 2, 573
Nystatin, 6, 241
Oxazepam, 3, 441
Oxytocin, 10, 563
Penicillamine, 10, 601
Phenazopyridine hydrochloride, 3, 465
Phenelzine sulfate, 2, 383
Phenformin hydrochloride, 4, 319; 5, 429
Phenobarbital, 7 , 359
Phenoxymethyl penicillin potassium, 1 , 249
Phenylephrine hydrochloride, 3, 483
Piperazine estrone sulfate, 5, 375
Primidone, 2, 409
Probenecid, 10, 639
Procainamide hydrochloride, 4 , 333
Procarbazine hydrochloride, 5, 403
Promethazine hydrochloride, 5, 429
Proparacaine hydrochloride, 6, 423
Propiomazine hydrochloride, 2, 439
Propoxyphene hydrochloride, 1, 301; 4, 519;

Propylthiouracil, 6, 457
Pseudoephedrine hydrochloride, 8, 489
Reserpine, 4, 384; 5, 557
Rifampin, 5 , 467
Salbutamol, 10, 665
Secobarbital sodium, 1, 343
Spironolactone, 4, 431
Sodium nitroprusside, 6, 487
Succinylcholine chloride, 10, 691
Sulphamerazine, 6, 515
Sulfamethazine, 7, 401
Sulfamethoxazole, 2, 467; 4, 520
Sulfasalazine, 5, 515
Sulfisoxazole, 2, 487
Testolactone, 5, 533
Testosterone enanthate, 4, 452
Theophylline, 4, 466
Thiostrepton, 7, 423
Tolbutamide, 3, 513; 5, 557
Triamcinolone, 1, 367; 2, 571; 4, 520, 523
Triamcinolone acetonide, 1, 397, 416; 2,

6, 598

571; 4,520; 7,501

Page 727

CUMULATIVE INDEX 735

Triamcinolone diacetate, 1, 423
Triamcinolone hexacetonide, 6, 579
Triclobisonium chloride, 2, 507
Trifluoperazine hydrochloride, 9, 543
Triflupromazine hydrochloride, 2, 523; 4,

Trimethaphan camsylate, 3, 545
Trimethobenzamide hydrochloride, 2, 551
Trimethoprim, 7, 445

520; 5, 557

Trioxsalen, 10, 705
Triprolidine hydrochloride, 8, 509
Tropicamide, 3, 565
Tubocurarine chloride, 7, 477
Tybamate, 4 , 494
Valproate sodium and valproic acid, 8, 529
Vinblastine sulfate, I, 443
Vincristine sulfate, I , 463

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