Download Advances in Rapid Sex-Steroid Action - G. Castoria, et. al., (Springer, 2012) WW PDF

TitleAdvances in Rapid Sex-Steroid Action - G. Castoria, et. al., (Springer, 2012) WW
TagsMedical
LanguageEnglish
File Size5.0 MB
Total Pages270
Table of Contents
                            001Download PDF (1.6 MB)front-matter
	Advances in Rapid
Sex-Steroid Action
		Preface
		Contents
		Contributors
002Download PDF (1.4 MB)front-matter
	Part I
Breast Cancer
003Download PDF (1.8 MB)fulltext
	2 ProgesteroneProgesterone Signaling to ChromatinChromatin in Breast Cancer Cells. Two Initial Cycles of Remodeling
		Abstract
		1…Introduction
		2…NucleosomeNucleosome Organization is Required for Efficient PR Binding and Gene Regulation
		3…Preparing the Chromatin for Gene Regulation
		4…BRCA1BRCA1 as a Physiological Brake for Hormone Action
		5…Conclusions
		Acknowledgments
		References
004Download PDF (1.8 MB)fulltext
	3 Cooperative Interactions Between c-Src, Estrogen Receptors and Receptor Tyrosine Kinases in Breast Cancer
		Abstract
		1…Introduction
		2…Canonical vs Rapid Signalingsignaling of Estrogen and the ERs
		3…Rapid Estrogen Signalingsignaling Involving ER, c-Srcc-Src and HER Family Members
			3.1 EstrogenEstrogen-Dependent c-Srcc-Src-ER Interactions: Complexes, Physiological Role, Mechanism of Action, and Regulation
			3.2 EstrogenEstrogen-Dependent HER Family and ER Interactions
			3.3 EstrogenEstrogen-Independent Interactions Between ER, c-Srcc-Src, and HER Family Members
			3.4 EstrogenEstrogen Receptor-Independent Actions of c-Srcc-Src and HER Family Members in Breast Cancerbreast cancer
		4…AR in Breast Cancerbreast cancer and Possible Interactions With ER, c-Srcc-Src, and HER Family Members
		5…ProgesteroneProgesterone Receptor Interactions With ER, c-Srcc-Src and HER Family Members
		6…Cancers Other Than Breast Cancerbreast cancer Whose Etiology is Influenced by the Estrogen Receptorestrogen receptor, c-Srcc-Src, and HER Family Members
		7…Role of c-Src/HER Family in Resistance to Hormone, Cytotoxic, or Targeted Therapies in Breast Cancerbreast cancer
			7.1 c-Srcc-Src as a Resistance Factor in Hormone, Cytotoxic, and Targeted Therapies in Breast Cancerbreast cancer
			7.2 c-Srcc-Src as a Resistance Factor to Hormonal Therapy in Breast Cancerbreast cancer
			7.3 c-Src and EGFR as Resistance Factors to Cytotoxic Therapies in Breast Cancerbreast cancer
			7.4 c-Srcc-Src and EGFR as Resistance Factors to Inhibitors of EGFR Family Members
		8…c-Srcc-Src/HER Family Targeted Therapies in Single Agent or Combinatorial Studies
			8.1 c-Srcc-Src Targeted Therapies
			8.2 EGFR and HER2 Inhibitors
		Acknowledgments
		References
005Download PDF (1.7 MB)fulltext
	4 Cross Talk Between ER alpha and Src Signaling and Its Relevance to ER Status and Hormone Responsiveness
		Abstract
		1…Estrogen Receptor in Breast Cancer
		2…Mechanisms Underlying ER Loss in Breast Cancer
			2.1 ER Gene Changes
			2.2 ER Promoter Hypermethylation
			2.3 ER mRNA Expression in Breast Cancerbreast cancers
			2.4 MAPK Activated Loss of ER Expression
		3…EGFR Family and Src Kinase Activation in Breast Cancer
		4…ER Cross-Talk with Signaling Transduction Pathways
		5…ER Phosphorylation by Src
		6…The Link Between Steroid Hormone Receptor Activation and Receptor Degradation
		7…Src Promotes Ligand Activated ER Degradation and ER Target Gene Transcription
		8…Implications for the Definition of an ‘‘Estrogen Responsive’’ Tissue
		References
006Download PDF (1.9 MB)fulltext
	5 Post-translational Modifications of ER Alpha in Rapid Estrogen’s Action
		Abstract
		1…Introduction
		2…PTMs Involved in ER Non-genomic Signaling
			2.1 Palmitoylation
			2.2 Phosphorylation on Tyrosine (Y)
			2.3 Arginine Methylation
		3…Conclusions
		Acknowledgments
		References
007Download PDF (1.7 MB)fulltext
	6 Sex-Steroid Rapid Action and Its Role in Invasiveness and Metastasis of Breast Cancer
		Abstract
		1…Introduction
		2…Non-genomic Actions by Steroid Hormones
			2.1 Rapid Action of Steroids Involving Classical Intracellular Steroid Receptors
			2.2 Rapid Action of Steroids Involving Non-classical 	Membrane-Bound Steroid Receptors
			2.3 Rapid Action of Membrane Steroid Receptors 	Involving G Protein-Coupled Receptors (GPCR)
			2.4 Rapid Action of Membrane Steroid Receptors via 	Trans-Activation of Growth Factor Receptors
			2.5 Rapid Non-transcriptional Action of Membrane 	Steroid Receptors
		3…Sex Steroids and Actin Cytoskeleton Remodeling
			3.1 Sex Steroids and Ezrin/Radixin/Moesin
			3.2 Sex Steroids and Focal Adhesion Kinase
		4…Sex Steroids and Tyrosine Kinase Receptor
		5…Sex Steroids and Other Metastasis-Associated Molecules
			5.1 Chemokines and Their Receptors
			5.2 Integrins
			5.3 Role of p52Shc in Steroid-Regulated Cell Proliferation and Migration
		6…Conclusions
		References
008Download PDF (1.6 MB)fulltext
	7 Unraveling the Role of GPERGper in Breast Cancer
		Abstract
		1…Introduction
		2…GPERGPER SignalingSignaling in Breast CancerBreast Cancer
		3…Binding Specificity and Biological Characterization of GPERGPER Ligands
		4…Implication of GPERGPER in the Resistance to Antiestrogen Therapy
		5…GPERGPER as a Biological Marker in Breast Carcinomas
		6…Conclusions
		Acknowledgments
		References
009Download PDF (1.7 MB)fulltext
	8 Nongenomic Actions of Estrogens and Xenoestrogens Affecting Endocrine Cancer Cells
		Abstract
		1…Introduction
		2…Receptors and the Signalingsignaling Responses and Functions Associated with Them
		3…Time-Oscillating Responses
		4…Hormesis-Nonmonotonic Responses
		5…Estrogenic Ligands: Physiologic and Non-physiologic
		6…Responses to Ligand Mixturesligand mixtures
		7…Developmental and Immune Systemimmune system Effects, Affecting Cancer
		8…Summary
		Acknowledgments
		References
010Download PDF (1.7 MB)fulltext
	1 Non-genomic Action of Steroid Hormones: More Questions than Answers
		Abstract
		1…Introduction
		2…Phenotype Dependence on Hormone Concentration: An Isolated Case or a General Rule?
		3…Migration and Proliferation Dichotomy Regulated by Rapid Hormonal Actions: A Step Towards Hormone Resistance?
		4…Non-Reproductive Cells Express Very Low Amounts of Steroid Receptors: A Model of ‘Pure’ Non-Genomic Receptor Action?
		5…Growth Factor Signaling Depends on Extra-Nuclear Steroid Receptors: Are Other Partners Implicated?
		6…Hetero-Association Between Steroid Receptors: A Tool to Enhance Hormone Signaling?
		7…The Proliferative Role of Steroid Receptor Nuclear Export: A Paradox of Classic Receptor Transcriptional Action?
		8…Receptor/Protein Associations: A Promising Target for Cancer Therapy?
		Acknowledgements
		References
011Download PDF (1.4 MB)front-matter
	Part II
Prostate Cancer
012Download PDF (1.8 MB)fulltext
	9 Differential Functions of Stromal and Epithelial Androgen Receptor in Prostate Cancer Before and After Castration Resistant Stage
		Abstract
		1…Introduction
		2…Epithelial AR Role in PCa
			2.1 Epithelial AR Role in In Vitro PCa Cell Line Studies (Growth vs. Invasion)
			2.2 Epithelial AR Role in PCa Mouse Model Studies (Initiation vs. Metastasis)
			2.3 AR Role in CK5-Positive vs. CK8-Positive PCa Cells
		3…Stromal AR Role in PCa
			3.1 Stromal AR Effect on Epithelial AR Activity
			3.2 Stromal AR Effect on Metastatic Potential of PCa
				3.2.1 In Vitro Stromal-Epithelial Co-Culture System
				3.2.2 In Vivo Cre-LoxP Stromal ARKO Mouse Model
				3.2.3 Stromal AR Role in BPH as Compared to PCa
				3.2.4 Stromal AR Role Effects on S/P Cells
			3.3 Stromal AR Role in Epithelial-Mesenchymal Transition (EMT)
		4…Therapeutic Approaches Targeting Differential Roles of AR
			4.1 Targeting Stromal/Luminal Epithelial AR with ASC-J9reg
			4.2 Combination Therapy of (1) Targeting Differential AR Roles in Different Tumor Stages and (2) Targeting Differential AR Roles in Various Cell Types
		References
013Download PDF (1.6 MB)fulltext
	10 Role of Androgens and Androgen Receptor in Prostate Cancer: Genomic and Non-Genomic Actions
		Abstract
		1…Introduction
		2…Non-Genomic Effects of AR in PCa Cells
		3…Role of Androgens and AR in the Pathogenesis and Development of PCa
		4…Role of Androgens and AR in Progression of PCa
		5…Conclusions
		References
014Download PDF (1.7 MB)fulltext
	11 Mechanisms of Signal Transduction in Prostate Cancer: The Role of PI3-Kinase Pathway in Androgen Action
		Abstract
		1…PI3Kinase/AKT Pathway and Prostate Cancer
			1.1 The PI3K Family
			1.2 AKT: The Main Transducer of the PI3K Signalingsignaling Pathway
		2…Deregulation of the PI3K Pathway and Prostate Cancer
		3…Rapid Androgen Response and PI3K Crosstalk in Prostate Cancer
			3.1 Genomic vs Non-genomic: the Two ‘‘Janus Faces’’ of Androgensandrogens Action
			3.2 Androgen Receptor Subcellular Localisation: Reconcile Transcription and Transduction
			3.3 Features of Activation and Interaction Between Androgen Receptor and PI3K
			3.4 In vivo Consequences of PI3K/AKT Modulation by Androgensandrogens
		References
015Download PDF (1.7 MB)fulltext
	12 The IGF-I Axis in Prostate Cancer: The Role of Rapid Steroid Actions
		Abstract
		1…Introduction
		2…Dysregulation of the IGF AxisIGF axis and Prostate Cancer
			2.1 Experimental Studies
			2.2 Epidemiology
		3…Cross-Talk Between Sex Steroids and the IGF AxisIGF axis
			3.1 The IGF-I ReceptorIGF-I receptor and Its Signalingsignaling Pathways
			3.2 IGF-I May Affect AR Transcriptional Activity
			3.3 IGF-IR and Membrane-Initiated Effects of Sex Steroids
		4…Sex Steroids Induce IGF-IR Up-Regulation via Membrane-Initiated Effects
			4.1 Effects of Androgensandrogens
			4.2 Effects of Estrogens
			4.3 Transcription Factors Involved
			4.4 IGF-IR Positive Feed-Back Loop Through CREB Activation
		5…Conclusions and Perspectives
		Conflict of interest
		References
016Download PDF (1.7 MB)fulltext
	13 Androgen Receptor Pathway in Prostate Cancer: Old Target and New Drugs
		Abstract
		1…Introduction
		2…AR Signaling in Prostate Cancer
		3…Targeting the AR Axis with New Molecules in CRPC
			3.1 Inhibition of Steroidogenic Pathways: AbirateroneAbiraterone 	and Other Compounds
			3.2 Androgen Receptor Antagonistsantagonists: MDV-3100MDV-3100 	and Other Compounds
		4…Perspectives: From AR Inhibition to Personalized Medicine
		5…Conclusion
		References
017Download PDF (1.4 MB)front-matter
	Part III
New Tools for Steroid Receptor Analysisand Regulatory Networks
018Download PDF (2.0 MB)fulltext
	14 Quantitative Visualization of Sex Steroid Receptor Functions: AR and ER alpha
		Abstract
		1…Introduction
			1.1 Gene Regulation
			1.2 Quantitative Imaging of Cell--Cell Heterogeneity
			1.3 High-Throughput Techniques for Studying Nuclear Receptor Biology
		2…Androgen Receptor
			2.1 Basic AR Biology
			2.2 Microscopy-Based AR Assays for Mechanistic Inquiry of AR Function
			2.3 FRAP/FRET Assays for Studying the Mechanisms of AR Activation
			2.4 High-Throughput Imaging for Characterizing Pathological AR Dysfunction Moving Towards Personalized Medicine
		3…Estrogen Receptor
			3.1 Basic ER Biology
			3.2 ER Dynamics and Chromatin Remodeling by Microscopy
			3.3 Using High-Throughput Microscopy to Study ER-Coregulator Interactions
		4…Conclusions
		Acknowledgments
		References
019Download PDF (1.9 MB)fulltext
	15 Micropatterned Surfaces as Tools for the Study of the Rapid Non-genomic Actions of Steroid Receptors
		Abstract
		1…Introduction
		2…Membrane Receptors
			2.1 Classical Intracellular Steroid Receptors as Membrane-Bound Steroid Receptor
				2.1.1 Mechanisms of Rapid Non-genomic ActionNon-Genomic Action of Steroid Receptors
				2.1.2 Physiologic Significance of the Rapid Action of Steroid Hormones
		3…Rapid Action of Steroids in Mast Cells
		4…Dip-Pen Nanolithography to Study Events at the IgE Receptor
		5…Questions to be Answered
		6…Conclusions
		Acknowledgments
		References
020Download PDF (1.6 MB)back-matter
	Index
                        

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